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Updated: Jul 10, 2026
06:09
Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
Published on: June 7, 2019
The T1799A BRAF mutation is present in iris melanoma
Fiona Henriquez1, Christoph Janssen, Ewan G Kemp
1School of Engineering and Science, University of Paisley, Paisley, Scotland, UK.
Investigative Ophthalmology & Visual Science
|October 27, 2007
Summary
The BRAF T1799A mutation was found in nearly half of iris melanoma samples, suggesting genetic differences from posterior uveal melanoma. This mutation was significantly associated with recurrent tumors.
Area of Science:
- Oncology
- Genetics
- Ophthalmology
Background:
- Activating BRAF mutations are common in cutaneous melanoma.
- Iris melanoma, a rare uveal melanoma subtype, has a less aggressive course.
- The BRAF T1799A mutation's prevalence in iris melanoma is unknown.
Purpose of the Study:
- To investigate the presence of the T1799A BRAF mutation in iris melanoma.
- To explore potential genetic distinctions between iris and posterior uveal melanomas.
Main Methods:
- DNA extraction from 19 archival iris melanoma tissue sections.
- Nested PCR amplification of BRAF exon 15.
- Sequencing and comparison with wild-type BRAF sequences.
Main Results:
- The T1799A BRAF mutation was detected in 9 out of 19 (47%) iris melanomas.
- A significant association was found between the BRAF mutation and tumor recurrence (P=0.003).
- No association was observed between the BRAF mutation and other clinicopathological features.
Conclusions:
- The T1799A BRAF mutation is present in a substantial proportion of iris melanomas.
- Findings suggest potential genetic and clinical differences between iris and posterior uveal melanomas.
- Further research is warranted to understand the implications of this mutation.
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