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Updated: Jul 10, 2026
04:08
Mouse Model of Surgical Uterine Injury and Subsequent Pregnancy Outcomes
Published on: June 27, 2025
Uterine rupture and perinatal outcome
Katarina Widén Pettersson1, Charlotta Grunewald, Peter Thomassen
1Department of Obstetrics and Gynecology, Stockholm South General Hospital, Stockholm, Sweden.
Acta Obstetricia Et Gynecologica Scandinavica
|October 27, 2007
Summary
Uterine rupture is rare, occurring in 0.9/1000 deliveries, often in women with prior uterine scars. Newborns had a low risk of long-term neurological issues despite some initial complications.
Area of Science:
- Obstetrics and Gynecology
- Perinatal Medicine
- Surgical Outcomes
Background:
- Investigating clinical aspects and perinatal outcomes of uterine rupture due to rising caesarean section (CS) rates.
- Retrospective analysis of 24,181 deliveries from 1999-2004 at Stockholm South General Hospital.
- Utilized ICD-codes 0710 and 0711, previous delivery records, and neonatal data.
Observation:
- Identified 22 cases of uterine rupture, with an incidence of 0.9 per 1,000 deliveries.
- Diagnosis confirmed via laparotomy in all cases.
- 19 out of 22 cases involved patients with a history of uterine scarring.
Findings:
- Uterine rupture occurred in 18 deliveries at term and one at 16 weeks gestation.
- One intrauterine fetal death was recorded.
- Of 20 live births, 9 had a 5-minute Apgar score ≤7; one neonate died within 3 days, and another experienced neurological sequelae.
Implications:
- A previous uterine scar is the primary risk factor for uterine rupture.
- The study highlights a relatively low risk of long-term post-asphyctic sequelae in newborns affected by uterine rupture.
- Emphasizes the importance of considering uterine scar history in managing deliveries.
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