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Related Experiment Video

Updated: Jul 10, 2026

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies

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Hormone replacement therapy in Denmark, 1995-2004.

Ellen Løkkegaard¹, Ojvind Lidegaard, Lisbeth Nørgaard Møller

¹Department of Obstetrics & Gynaecology, Rigshospitalet, Copenhagen, Denmark.

Acta Obstetricia Et Gynecologica Scandinavica

|October 27, 2007

Summary

Hormone replacement therapy (HRT) use significantly declined in Denmark after 2002, particularly among women aged 50-59. Factors like education, employment, and urban living influenced HRT use, which also correlated with other health medications.

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Area of Science:

Reproductive Endocrinology
Public Health Policy
Pharmaceutical Medicine

Background:

Danish National Register of Medicinal Product Statistics (NRM) now accessible for research, enabling individual-level data linkage.
Opportunity to analyze hormone usage across the entire Danish female population, focusing on systemic hormone replacement therapy (HRT) regimens and associated factors.

Purpose of the Study:

To analyze hormone utilization patterns in the Danish female population.
To conduct a detailed evaluation of specific hormone replacement therapy (HRT) regimens.
To identify factors associated with systemic HRT use.

Main Methods:

Utilized Danish Civil Registration System and NRM for data on 15-70 year old females (1995-2004).
Retrieved prescriptions for hormones and medications for diabetes, hypertension, hypercholesterolemia, and heart conditions.
Integrated data on habitation, education, employment, and gynecological surgery from national registers.

Main Results:

HRT use decreased by 65% after 2002; prevalence was highest in women aged 55-59 (200 DDD/1000 women/day in 2002).
Approximately 39% of women aged 50-57 were ever exposed to HRT, with a mean duration of 5 years.
HRT use declined significantly, initially cyclic combined therapy, then continuous combined therapy post-2002; associated with education, employment, urban living, and use of antiarrhythmics/antihypertensives; inversely associated with diabetes treatment.

Conclusions:

One in five women aged 50-59 used HRT daily; usage declined substantially post-2002.
HRT use is linked to the use of other significant health-related medications.
Significant shifts in HRT prescribing patterns observed, influenced by various demographic and health factors.