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Updated: Jul 10, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
Enteric controlled-release pantoprazole-loaded microparticles prepared by using Eudragit S100 and
Renata Platcheck Raffin1, Leticia Marques Colomé, Silvia Stanisçuaski Guterres
1Faculdade de Farmácia - Universidade Federal do Rio Grande do Sul, Brazil.
Abstract:
Microparticles of poly(epsilon-caprolactone) and of its blend with Eudragit S100 were prepared by emulsion/solvent evaporation technique to provide controlled release and gastro-resistance for an acid labile drug. This drug was sodium pantoprazole, a proton pump inhibitor. Both formulations were successfully prepared, but only the microparticles prepared with the blend were capable of stabilizing the drug in the acid medium. Furthermore, this formulation showed in vivo protection of stomachs against ulceration caused by ethanol in rats. These microparticles were tabletted, and the tablets demonstrated slower drug release and higher acid protection than the microparticles before tabletting.
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