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Updated: Jul 10, 2026

Formation of Dispersible Taohong Siwu Tablets
Published on: February 3, 2023
The effect of binary mixture composition and magnesium stearate concentration on the Hiestand Tableting Indices and
Sukhon Likitlersuang1, Dale Eric Wurster, Yisheng Chen
1Division of Pharmaceutics, College of Pharmacy, The University of Iowa, Iowa City, IA 52242, USA.
Abstract:
Maltodextrins were chosen as model excipients because maltodextrins possess a series of molecular weights that showed systematically changing consolidation mechanisms. As maltodextrin molecular weight increases, the plasticity of the material increases. Three commercial grades of Maltrin (M040, M100, and M150) were used to prepare binary powder mixtures (M040-M150 and M040-M100). For each mixture, magnesium stearate was added at concentrations of 0%, 0.16%, 0.32%, 0.48%, and 0.64%. The Hiestand Tableting Indices and other related mechanical properties were used to quantify the effects of magnesium stearate addition on the compaction properties of the binary mixtures. Linear relationships were observed between the Hiestand Bonding Indices and the compositions of the compacts in the absence of magnesium stearate. However, the Hiestand Bonding Indices were related to compact compositions in polynomial fashion when magnesium stearate was present in the binary mixtures. The Hiestand Brittle Fracture Indices varied with compact compositions in polynomial fashion with and without magnesium stearate.
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