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Updated: Jul 10, 2026

Functional Interrogation of Adult Hypothalamic Neurogenesis with Focal Radiological Inhibition

Functional Interrogation of Adult Hypothalamic Neurogenesis with Focal Radiological Inhibition

Published on: November 14, 2013

Radiation effects on development.

Marco De Santis¹, Elena Cesari, E Nobili

¹Telefono Rosso-Teratology Information Service, Department of Obstetrics and Gynecology, Catholic University, Largo Agostino Gemelli 1, Rome, Italy. marcodesantis@rm.unicatt.it

Birth Defects Research. Part C, Embryo Today : Reviews

|October 30, 2007

Summary

This summary is machine-generated.

Prenatal radiation exposure impacts embryonic and fetal development, with effects varying by dose and gestational age. Understanding cumulative radiation dose and developmental stage is crucial for counseling pregnant women.

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Area of Science:

Medical Science
Radiology
Developmental Biology

Background:

Prenatal exposure to ionizing radiation is known to affect embryonic and fetal development.
Effects are dependent on radiation dose and gestational age at exposure.
Animal models show distinct teratogenic effects at different prenatal stages.

Purpose of the Study:

To review the impact of prenatal radiation exposure on fetal development.
To emphasize the importance of cumulative dose and gestational age for risk assessment.
To guide appropriate counseling for pregnant women regarding radiation exposure.

Main Methods:

Literature review of studies on prenatal radiation exposure.
Analysis of teratogenic effects across different developmental stages (preimplantation, organogenesis, fetogenesis).
Comparison of effects observed in animal models and human studies.

Main Results:

High radiation doses can cause abortion or genomic damage during preimplantation.
Organogenesis stage exposure (days 6.5-13.5 in mice) is linked to malformations and intrauterine growth restriction (IUGR).
Later exposure primarily affects brain development; diagnostic doses in humans (<0.05 Gy) generally do not increase congenital anomaly risk.

Conclusions:

Adverse outcomes in humans mirror animal studies, varying with developmental stage.
Blastogenesis is associated with implantation failure or no effects.
Organogenesis exposure increases malformation/growth retardation risk, while fetogenesis exposure impacts brain development.