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Updated: Jul 10, 2026

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
Published on: January 22, 2019
Discovery of potent and selective adamantane-based small-molecule P2X(7) receptor antagonists/interleukin-1beta
Mark Furber1, Lilian Alcaraz, Janice E Bent
1Department of Medicinal Chemistry, AstraZeneca R&D Charnwood, Bakewell Road, Loughborough, Leics, U.K. mark1.furber@astrazeneca.com
Abstract:
A novel series of antagonists of the human P2X7 receptor is described. Modification of substituents enabled identification of compounds selective for the rat P2X7 receptor and provides useful pharmacological tools for evaluation of the role of P2X7 in disease.
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