Related Experiment Video

Updated: Jul 10, 2026

Multiomics Analysis of TMEM200A as a Pan-Cancer Biomarker
07:47

Multiomics Analysis of TMEM200A as a Pan-Cancer Biomarker

Published on: September 15, 2023

PI3K/PTEN signaling in tumorigenesis and angiogenesis

Bing-Hua Jiang1, Ling-Zhi Liu

  • 1Cancer Center, Department of Pathology, Nanjing Medical University, Nanjing, Jiangsu, China. bhjiang@njmu.edu.cn

Biochimica Et Biophysica Acta
|October 30, 2007
PubMed

Insights

The phosphatidyl inositol 3-kinase (PI3K)/PTEN pathway is frequently altered in cancers and drives tumor growth and angiogenesis. Targeting this pathway offers potential therapeutic strategies for cancer treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • The phosphatidyl inositol 3-kinase (PI3K) pathway regulates critical cellular functions like proliferation, survival, and protein synthesis.
  • PTEN acts as a crucial antagonist to PI3K, and its dysregulation, along with PI3K pathway alterations, is common in human cancers.
  • Tumor growth and metastasis beyond 1 mm in diameter necessitate angiogenesis, a process significantly influenced by the PI3K pathway.

Purpose of the Study:

  • To review recent advancements in understanding the PI3K/PTEN pathway.
  • To elucidate the role and mechanisms of PI3K in regulating tumor growth and angiogenesis.
  • To explore potential therapeutic opportunities targeting the PI3K pathway in cancer.

Main Methods:

  • Literature review of recent studies on the PI3K/PTEN pathway.
  • Analysis of PI3K's role in regulating tumor growth and angiogenesis via VEGF and HIF-1 expression.
  • Investigation of PI3K's regulatory mechanisms involving HDM2 and p70S6K1.

Main Results:

  • PI3K and Akt are integral to tumor growth and angiogenesis, mediated through VEGF and HIF-1 expression.
  • PI3K influences VEGF and HIF-1 expression via HDM2 and p70S6K1 in human cancer cells.
  • Frequent dysregulation of the PI3K/PTEN pathway highlights its significance in oncogenesis.

Conclusions:

  • The PI3K/PTEN pathway is a critical regulator of tumor growth and angiogenesis.
  • Dysregulation of this pathway is a hallmark of many human cancers.
  • Targeting the PI3K/PTEN pathway presents a promising therapeutic avenue for cancer treatment.

More Related Videos

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway07:15

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway

Published on: August 23, 2024

Related Concept Videos

PI3K/mTOR/AKT Signaling Pathway01:22

PI3K/mTOR/AKT Signaling Pathway

The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a rapamycin-insensitive companion...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...