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Updated: Jul 10, 2026

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells
Published on: November 23, 2014
[Angiogenesis targeting in breast cancer]
Pierre Fumoleau1, Bruno Coudert, Françoise Mayer
1Centre Georges-François Leclerc, rue du Professeur-Marion, 21079 Dijon. PFumoleau@dijon.fnclcc.fr
Bevacizumab combined with paclitaxel improves relapse-free survival in metastatic breast cancer. However, anti-angiogenic combinations show increased toxicity and inconsistent survival benefits, limiting predictive factor studies.
Area of Science:
- Oncology
- Pharmacology
Context:
- Breast cancer treatment landscape.
- Emerging role of anti-angiogenic agents.
Purpose:
- Evaluate efficacy and toxicity of anti-angiogenic agents in breast cancer.
- Investigate combination therapies.
Summary:
- Bevacizumab with paclitaxel shows efficacy in metastatic breast cancer for relapse-free survival.
- Combination targeted therapies are of interest but face challenges.
- Anti-angiogenic agents in Phase III trials have inconsistent survival benefits and increased toxicity.
- Obtaining tissue samples for predictive factor analysis is difficult outside the neo-adjuvant setting.
Impact:
- Highlights the complex role of anti-angiogenic therapies in breast cancer.
- Underscores the need for predictive biomarkers and careful toxicity monitoring.
- Informs future clinical trial design and therapeutic strategies.
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