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Updated: Jul 10, 2026

Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy
11:27

Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy

Published on: April 29, 2014

[Angiogenesis targeting in renal carcinomas]

Damien Pouessel1, Stephane Culine

  • 1Département d'oncologie médicale, Centre régional de lutte contre le cancer Val d'Aurelle, Parc Euromédecine, 34298 Montpellier cedex 5.

Bulletin Du Cancer
|November 6, 2007
PubMed

Insights

Sunitinib is a preferred first-line treatment for metastatic clear cell renal carcinoma over sorafenib, showing better response and progression-free survival. Both drugs target VEGF receptors but have different side effects and may exhibit cross-resistance.

Area of Science:

  • Oncology
  • Pharmacology
  • Translational Medicine

Background:

  • Metastatic clear cell renal carcinoma (ccRCC) treatment is evolving.
  • Angiogenesis inhibitors targeting VEGF receptors are key therapeutic agents.

Purpose of the Study:

  • To compare the efficacy and toxicity of sunitinib and sorafenib in metastatic ccRCC.
  • To evaluate their roles in first-line treatment strategies.

Main Methods:

  • Review of available clinical data and trial results for sunitinib and sorafenib.
  • Analysis of response rates and progression-free survival (PFS).
  • Comparison of toxicity profiles.

Main Results:

  • Sunitinib demonstrates superior efficacy compared to sorafenib in terms of response and PFS.
  • Both agents are active in metastatic ccRCC, with immunotherapy reserved for specific cases.
  • Distinct toxicity profiles necessitate individualized treatment selection.

Conclusions:

  • Sunitinib is recommended as a first-line treatment for metastatic ccRCC.
  • Individualized treatment selection based on toxicity profiles is crucial.
  • Potential for partial cross-resistance between sunitinib and sorafenib warrants further investigation.

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