Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Type II Diabetes I: Introduction01:26

Type II Diabetes I: Introduction

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, in which target tissues such as the liver, muscle, and adipose tissue respond poorly to insulin. It is also associated with inadequate compensatory insulin secretion, where pancreatic β-cells fail to produce sufficient insulin. Together, these abnormalities lead to persistent hyperglycemia.EtiologyT2DM develops through a complex interaction of genetic predisposition and environmental or...
Type II Diabetes II: Pathophysiology01:24

Type II Diabetes II: Pathophysiology

PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis01:25

Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis

Type 2 diabetes mellitus develops gradually and is often asymptomatic in early stages.Clinical ManifestationsWhen symptoms appear, they include fatigue, blurred vision, pruritus, delayed wound healing, and recurrent infections, particularly candidal infections. Peripheral neuropathy may present as numbness or tingling in the extremities. Classic hyperglycemia symptoms—polyuria, polydipsia, and polyphagia—are less common. Most patients are overweight and frequently have associated hypertension...
Carbohydrate Metabolism01:36

Carbohydrate Metabolism

Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Missing infrastructure for real-world predictive AI impact.

BMJ health & care informatics·2026
Same author

Prevalence of liver fibrosis in the general population (the LiverScreen project): a multinational European cohort study.

Lancet (London, England)·2026
Same author

Association between changes in adherence to the planetary health diet and adiposity and body fat distribution: a cohort study.

The Lancet regional health. Europe·2026
Same author

Cardiometabolic prediction models for young people with psychosis spectrum disorders in the UK (PsyMetRiC 2.0): a retrospective, multicohort clinical prediction model study.

The lancet. Psychiatry·2026
Same author

Sex-specific differences in the prevalence of intermediate hyperglycaemia states: A systematic review and meta-analysis.

Diabetic medicine : a journal of the British Diabetic Association·2026
Same author

Assessment of the performance of non-invasive risk models to predict incident type 2 diabetes in a Swedish population - Västerbotten Intervention Programme.

Diabetes & metabolic syndrome·2026

Related Experiment Video

Updated: Jul 10, 2026

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid
06:21

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid

Published on: April 7, 2023

Does depression increase the risk of developing type 2 diabetes?

Martin P Cosgrove1, Lincoln A Sargeant, Simon J Griffin

  • 1Cherry Hinton Medical Centre, 34 Fishers Lane, Cambridge CB1 9HR, UK. drmartincosgrove@yahoo.co.uk

Occupational Medicine (Oxford, England)
|October 30, 2007
PubMed
Summary

Depression is linked to a higher risk of developing type 2 diabetes. However, the association is modest, with depression contributing to only 20% of diabetes cases in affected individuals.

Related Experiment Videos

Last Updated: Jul 10, 2026

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid
06:21

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid

Published on: April 7, 2023

Area of Science:

  • Epidemiology
  • Public Health
  • Medical Research

Background:

  • Work-related depression is sometimes claimed to cause diabetes for injury pension eligibility.
  • Understanding the link between depression and diabetes is crucial for pension claims.

Purpose of the Study:

  • To quantify the association between depression and the subsequent development of type 2 diabetes.
  • To inform decisions regarding injury pensions for individuals with diabetes following depressive episodes.

Main Methods:

  • Systematic literature review of cohort studies up to December 2006.
  • Pooled relative risk estimates using fixed and random effects models.
  • Calculated attributable risk fraction using the Levin formula.

Main Results:

  • Depression or depressive symptoms show an increased risk of developing type 2 diabetes.
  • The pooled relative risk from high-quality studies was 1.25 (95% CI: 1.02-1.48), indicating a homogenous association.
  • No significant difference in depression prevalence was found between those with and without previously undiagnosed type 2 diabetes.

Conclusions:

  • A clear association exists between depression and the subsequent development of type 2 diabetes.
  • The relative risk is small, with depression accounting for only 20% of diabetes cases in individuals with both conditions.
  • Further research is needed to explore causal mechanisms and potential common etiologies.