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Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Asthma-II: Pathophysiology and Classification01:26

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
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Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
08:47

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Published on: March 3, 2023

Environmental factors and allergic disorders.

Keiko Tanaka1, Yoshihiro Miyake, Chikako Kiyohara

  • 1Department of Public Health, Faculty of Medicine, Fukuoka University, Fukuoka, Japan. k-tanaka@fukuoka-u.ac.jp

Allergology International : Official Journal of the Japanese Society of Allergology
|October 30, 2007
PubMed
Summary

Environmental factors show inconsistent links to allergic diseases like asthma. While heredity appears linked to allergies, more research, especially in Asian populations, is needed to confirm environmental causes.

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Area of Science:

  • Epidemiology
  • Environmental Health
  • Allergy Research

Background:

  • Numerous studies explore links between environmental factors and allergic disorders, but findings remain controversial.
  • Allergic diseases, including wheeze, asthma, atopic dermatitis, and allergic rhinitis, affect global populations.
  • Existing research predominantly originates from Western countries, limiting applicability to diverse populations.

Purpose of the Study:

  • To review and synthesize evidence on environmental and nutritional determinants of allergic diseases.
  • To assess the strength and consistency of associations between environmental exposures and allergic conditions.
  • To identify gaps in current research, particularly regarding non-Western populations.

Main Methods:

  • Systematic review of 1093 papers published since 2000 from PubMed.
  • Inclusion of 263 articles focusing on epidemiological studies of environmental factors and allergic diseases.
  • Analysis primarily included cross-sectional, case-control, and prospective cohort studies.

Main Results:

  • Inconsistent associations were found between various environmental factors and the risk of allergic disorders.
  • Evidence was insufficient to establish a causal relationship between environmental exposures and allergic diseases.
  • A suggestive positive association was observed between allergies and heredity.

Conclusions:

  • Current evidence is inadequate to confirm environmental causes for allergic diseases.
  • Heredity is a potential contributing factor to allergies.
  • Further population-based prospective cohort studies, especially in Asian populations, are crucial for understanding environmental influences on allergic diseases.