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Indigofera suffruticosa: an alternative anticancer therapy.
Jeymesson Raphael Cardoso Vieira1, Ivone Antônia de Souza, Silene Carneiro do Nascimento
1Universidade Federal de Pernambuco/Departamento de Patologia do Centro de Ciências da Saúde Recife-PE, Brazil.
Evidence-Based Complementary and Alternative Medicine : Ecam
|October 30, 2007
Summary
Aqueous extracts from Indigofera suffruticosa leaves show low toxicity and significant antitumor effects against sarcoma 180 in mice. These findings suggest its potential as a natural anticancer agent.
Area of Science:
- Phytochemistry
- Pharmacology
- Natural Products
Background:
- Indigofera suffruticosa Mill (Fabeceae) is a plant used in traditional medicine for infectious and inflammatory conditions.
- Its potential therapeutic properties warrant scientific investigation.
Purpose of the Study:
- To evaluate the cytotoxic and antitumor effects of aqueous leaf extracts of Indigofera suffruticosa.
- To assess the toxicological properties of these extracts.
Main Methods:
- Aqueous extracts were prepared by infusion and maceration.
- Cytotoxicity was assessed using the MTT assay against HEp-2 cell lines.
- Antitumor activity was evaluated against sarcoma 180 in mice.
- Toxicological assays were performed.
Main Results:
- Aqueous extracts showed no cytotoxicity against HEp-2 cells.
- Extracts exhibited low toxicity in toxicological assays.
- Significant antitumor effects were observed: 64.53% inhibition with infusion and 62.62% with maceration against sarcoma 180.
Conclusions:
- Indigofera suffruticosa leaf extracts demonstrate a low toxicity profile.
- The extracts show considerable efficacy in inhibiting solid tumor growth.
- These findings support the use of Indigofera suffruticosa as a potential alternative anticancer agent.
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