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Related Experiment Video

Updated: Jul 10, 2026

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

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[Human seminal plasma allergy type I].

U M Winter¹, W Harth, R Treudler

¹Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Leipzig AöR, Philipp-Rosenthal-Str. 23-25, 04103 Leipzig. ulrike.winter@medizin.uni-leipzig.de

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete

|October 30, 2007

Summary

Human seminal plasma allergy (HSPA) is a rare condition causing allergic reactions to semen proteins. Diagnosis involves history, skin tests, and IgE levels, as seen in a patient with urticaria after intercourse.

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Area of Science:

Allergology and Immunology
Reproductive Medicine

Background:

Human seminal plasma allergy (HSPA) is a rare hypersensitivity reaction.
It involves allergic responses to specific protein fractions within seminal fluid.
Prostate-Specific Antigen (PSA) is identified as a significant allergen in HSPA.

Observation:

The case study focuses on a patient experiencing recurrent generalized urticaria.
Symptoms manifested after unprotected sexual intercourse.
The patient exhibited a positive prick test reaction to seminal plasma.

Findings:

The patient's symptoms align with Type I-immunoreactions, a common presentation of HSPA.
Diagnosis was confirmed through clinical history, skin testing, and specific IgE level determination.
Recurrent urticaria episodes were directly linked to exposure to seminal plasma.

Implications:

This case highlights the importance of considering HSPA in patients with unexplained urticaria post-coitus.
Accurate diagnosis relies on a combination of clinical evaluation and specific immunological tests.
Understanding seminal plasma allergens like PSA is crucial for managing HSPA effectively.