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Updated: Aug 5, 2026

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
Published on: December 10, 2013
[The efficacy of ribamidil in experimental RS-virus infection]
Abstract:
The antiviral activity of a national analogue of virasol, ribamydil, with regard to RS virus infection was studied in tissue culture and in experimental animals. In L-41 cell cultures ribamydil in a dose of 60 micrograms/ml or more completely inhibited multiplication of RS virus strain Long, in a titre of 4.75 lg CPD50. The drug concentrations of 30, 15, and 7 micrograms/ml reduced the virus content by 3.75, 2.75 and 2.0 lg CPD50, respectively; ED50 of the drug was 7 micrograms/ml, the chemotherapeutic index was 71. In cotton rats, RS virus infection could be reproduced in 95%. Subcutaneous inoculation of the injection form of ribamydil in a dose of 100 mg/kg body weight prevented the development of infection with RS virus in 100% of the animals.
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