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Monitoring Leucine-Rich Repeat Containing 8 Channel (LRRC8/VRAC) Activity Using Sensitized-Emission Förster Resonance Energy Transfer (SE-FRET)
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Syntaxin 8 has two functionally distinct di-leucine-based motifs.

Kazuo Kasai1, Kei Suga, Tetsuro Izumi

  • 1Department of Cell Physiology, Kyorin University School of Medicine, Mitaka, Tokyo, 181-8611, Japan.

Cellular & Molecular Biology Letters
|October 30, 2007
PubMed
Summary

Syntaxin 8 utilizes two distinct di-leucine motifs in its cytoplasmic domain for independent endocytic and exocytic transport. This finding clarifies the molecular mechanisms governing syntaxin 8 plasma membrane cycling.

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