Related Experiment Video
Updated: Jul 10, 2026

Intra-Peritoneal Transplantation for Generating Acute Myeloid Leukemia in Mice
Published on: January 6, 2023
[Brain abscess induced by Bacillus licheniformis complications in acute myeloid leukemia (AML)]
Yasuhiro Mochiduki1, Tokunao Amemiya, Masami Yabe
1Hematology/Transplantation, Seirei Numazu Hospital.
Abstract:
A 64-year-old woman with acute myeloid leukemia, headache, vomiting, and fever exceeding 38.5 degrees C on day 15 during severe neutropenia while undergoing second consolidation chemotherapy presented the next day, with an altered mental state. A space-occupying lesion with ring enhancement was detected in her right frontal lobe on CT, indicting a brain abscess. Treatment was started with 2g/day of meropenem and 2 g/day of vancomycin. Surgical drainage was conducted on day 22 after recovery of her neutrophil and platelet counts. Culture of aspirated pus showed Gram-positive rods subsequently identified as Bacillus licheniformis. Meropenem was administered for 87 days and vancomycin for 44 days. The patient's general condition improved without neurological complications, and her enhanced brain lesion disappeared on day 185. B. licheniformis is often encountered in diagnostic laboratory culture and usually dismissed as a contaminant, but must be considered as a causative agents for brain abscesses in immunocompromised hosts.
Related Concept Videos
Brain Abscess l: Introduction
Bacterial Meningitis I: Introduction
Disorders of Leukocytes
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...
Inhalation Anthrax
Cryptococcal Meningitis
Bacterial Meningitis