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Related Concept Videos

Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
Carbohydrate Metabolism01:36

Carbohydrate Metabolism

Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in the...
Type II Diabetes I: Introduction01:26

Type II Diabetes I: Introduction

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, in which target tissues such as the liver, muscle, and adipose tissue respond poorly to insulin. It is also associated with inadequate compensatory insulin secretion, where pancreatic β-cells fail to produce sufficient insulin. Together, these abnormalities lead to persistent hyperglycemia.EtiologyT2DM develops through a complex interaction of genetic predisposition and environmental or...
Type II Diabetes II: Pathophysiology01:24

Type II Diabetes II: Pathophysiology

PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.
Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis01:25

Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis

Type 2 diabetes mellitus develops gradually and is often asymptomatic in early stages.Clinical ManifestationsWhen symptoms appear, they include fatigue, blurred vision, pruritus, delayed wound healing, and recurrent infections, particularly candidal infections. Peripheral neuropathy may present as numbness or tingling in the extremities. Classic hyperglycemia symptoms—polyuria, polydipsia, and polyphagia—are less common. Most patients are overweight and frequently have associated hypertension...
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...

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[Sitagliptine (Januvia): incretin enhancer potentiating insulin secretion for the treatment of type 2 diabetes].

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Related Experiment Video

Updated: Jul 10, 2026

An Assay to Detect Protection of the Retinal Vasculature from Diabetes-Related Death in Mice
04:36

An Assay to Detect Protection of the Retinal Vasculature from Diabetes-Related Death in Mice

Published on: January 12, 2024

[Does coffee protect against type 2 diabetes?].

D Legrand1, A J Scheen

  • 1Service de Diabétologie, Nutrition et Maladies métaboliques, Département de Médecine et Unité de Pharmacologie clinique, CHU Sart Tilman, Liège, Belgique.

Revue Medicale De Liege
|October 31, 2007
PubMed
Summary

Coffee consumption may significantly lower the risk of developing type 2 diabetes. This protective effect appears consistent across various populations and coffee types, including decaffeinated options.

Area of Science:

  • Nutrition Science
  • Epidemiology
  • Public Health

Background:

  • Type 2 diabetes prevention is a critical public health goal.
  • Previous cross-sectional studies indicated a lower prevalence of type 2 diabetes in coffee drinkers.

Purpose of the Study:

  • To synthesize findings from recent prospective studies on coffee consumption and type 2 diabetes risk.
  • To evaluate the protective effect of coffee against type 2 diabetes development.

Main Methods:

  • Review and synthesis of recent prospective cohort studies.
  • Assessment of relative risk for type 2 diabetes based on coffee consumption levels.

Main Results:

  • Most studies confirm a protective effect of coffee against type 2 diabetes.

Related Experiment Videos

Last Updated: Jul 10, 2026

An Assay to Detect Protection of the Retinal Vasculature from Diabetes-Related Death in Mice
04:36

An Assay to Detect Protection of the Retinal Vasculature from Diabetes-Related Death in Mice

Published on: January 12, 2024

  • A dose-response relationship was observed, with higher consumption linked to greater risk reduction (relative risk 0.70-0.40).
  • Decaffeinated coffee showed a similar or even greater protective effect than regular coffee.

    • Conclusions:

    • The protective effect of coffee against type 2 diabetes is likely due to components other than caffeine, such as chlorogenic acid and antioxidants.
    • Further research is needed to elucidate the precise mechanisms and public health implications of coffee's protective role.