Related Experiment Videos
[Genetic and immunological aspects of the pathogenesis of psoriasis]
Adam Reich1, Jacek Szepietowski
1Katedry i Kliniki Dermatologii, Wenerologii i Alergologii Akademii Medycznej we Wrocławiu. adi_medicalis@go2.pl
Abstract:
Psoriasis is a chronic, inflammatory skin disorder, which occurs in about 1-3% of general population. Skin lesions are a result of hyperproliferation of epidermis and of time shortening of the transposition of keratinocytes from basal to corneal layer of epidermis. In healthy subjects this time is estimated on about 26-28 days, whereas in psoriatic individuals lasts only 3-4 days. Despite many investigations, the etiopathogenesis of psoriasis still remains unclear. Observations that psoriasis could occur in the same family members, indicated the importance of genetic factors. Moreover, high effectiveness of immunosuppressive drugs in the treatment of psoriasis suggested also a significant role of immune system in the development of this disease. Here, we present the current knowledge on the role of genetic and immunological factors in the development of psoriasis.
Related Concept Videos
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Autoimmune Disorders
Concept and Mechanism of Autoimmune Diseases
The immune system...
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
Inflammatory Bowel Disease III: Crohn's Disease
Skin Diseases and Disorders
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Human Genetics
The complex relationship between genetics and psychology is observable through common biological components such...