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Updated: Jul 10, 2026

Tissue Engineering of the Intestine in a Murine Model
Published on: December 1, 2012
[Short bowel syndrome due to a severe complication related to Meckel's diverticulum]
Abstract:
A 17 years old patient, admitted and operated in emergency with acute diffuse peritonitis which had been had the onset four days before. During surgery, a huge volvulus of the small intestine is revealed due to an adherence between Meckel's diverticulum and mesentery, with large intestinal necrosis. Extended enterectomy is performed with jejunostomy. The postoperative outcome is difficult due to severe metabolic insufficiencies which are managed by intensive therapy measures. The patient is readmitted to surgery and an anastomosis between 30 cm jejunum and 20 cm ileum is performed. Then the outcome is good, with digestive function recovery and weight gain. Unfortunately, the patient died one year after surgery, due to severe haematological and neurological disorders caused by the mal-absorbtion syndrome.
Insights
A young patient experienced acute peritonitis due to a small intestine volvulus caused by Meckel's diverticulum. Despite surgical intervention and recovery, long-term complications from malabsorption syndrome led to a fatal outcome.
Area of Science:
- Gastroenterology
- Surgical Pathology
Background:
- Acute diffuse peritonitis in a 17-year-old patient presenting with a four-day history of symptoms.
- Emergency surgical admission and intervention were required.
Observation:
- Intraoperative findings revealed a massive small intestine volvulus.
- The volvulus was caused by an adhesion between Meckel's diverticulum and the mesentery.
- Extensive intestinal necrosis was observed, necessitating significant resection.
Findings:
- An extended enterectomy was performed, followed by the creation of a jejunostomy.
- Postoperative course was complicated by severe metabolic insufficiencies requiring intensive therapy.
- A second surgery involved creating an anastomosis between 30 cm of jejunum and 20 cm of ileum.
Implications:
- Initial recovery showed improved digestive function and weight gain post-anastomosis.
- However, the patient ultimately succumbed one year later.
- Severe hematological and neurological disorders, secondary to malabsorption syndrome, were the cause of death.
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