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Effect of cisplatin on lipid peroxidation in blood platelets
1Department of Biochemistry, University of Lódź, Poland.
Acta Biochimica Polonica
|January 1, 1991
Abstract:
Cisplatin (cis-diamminedichloroplatinum II) at the concentrations of 2-20 micrograms induces non-enzymatic peroxidation of pig platelet lipids. At low concentration (0.1 microgram) it inhibits the enzymatic thrombin-stimulated transformation of platelet endogenous arachidonic acid. This drug also reduces the activities of platelet enzymes: superoxide dismutase and glutathione peroxidase.

