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Related Experiment Video

Updated: Jul 10, 2026

Induction of Microstreaming by Nonspherical Bubble Oscillations in an Acoustic Levitation System
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Induction of Microstreaming by Nonspherical Bubble Oscillations in an Acoustic Levitation System

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Mapping elasticity in human lenses using bubble-based acoustic radiation force.

Kyle W Hollman, Matthew O'Donnell, Todd N Erpelding

    Experimental Eye Research
    |October 31, 2007
    PubMed
    Summary

    This study measured human lens elasticity using acoustic radiation pressure and ultrasound. Older lenses are stiffer, especially in the center, offering insights into accommodation mechanics.

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    Area of Science:

    • Biomedical Engineering
    • Ophthalmology
    • Acoustics

    Background:

    • Investigates age-related changes in human lens elasticity.
    • Employs acoustic radiation pressure to displace femtosecond laser-induced bubbles.
    • Utilizes high-resolution ultrasound for precise bubble displacement monitoring.

    Discussion:

    • Young's modulus determination is inversely proportional to compensated bubble displacement.
    • Bubble size compensation is achieved using ultrasonic backscatter.
    • Methodology validated against controlled gelatin samples.

    Key Insights:

    • Middle-age lenses (approx. 40 yrs) show Young's modulus from 5.2kPa (center) to 1.1kPa (periphery).
    • Old-age lenses (63-70 yrs) exhibit higher Young's modulus: 10.6kPa (center) to 1.4kPa (periphery).

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  • Elasticity distribution changes with age, consistent with prior research.

    • Outlook:

    • Findings align with previous elasticity measurements using alternative techniques.
    • Radially varying elasticity may elucidate the biomechanical mechanisms of accommodation.
    • This acoustic technique offers a novel approach for lens biomechanics research.