Related Experiment Videos
Osteonectin is an alpha-granule component involved with thrombospondin in platelet aggregation
P Clezardin1, L Malaval, M C Morel
1INSERM U 234, Laboratoire de Biochimie des Protéines Osseuses, Hôpital Edouard Herriot, Lyon, France.
Summary
Osteonectin is stored in human platelet alpha-granules and its deficiency causes gray platelet syndrome. Anti-osteonectin antibodies inhibit platelet aggregation by reducing thrombospondin surface expression.
Area of Science:
- Hematology
- Platelet Biology
- Protein Biochemistry
Background:
- Osteonectin, a phosphoglycoprotein found in bone and platelets, forms a complex with thrombospondin.
- The storage and function of osteonectin within platelets remain largely uncharacterized.
- Gray platelet syndrome is a rare bleeding disorder linked to deficient platelet alpha-granules.