Type II collagen autoimmunity in a mouse model of human rheumatoid arthritis
Young-Gyu Cho1, Mi-La Cho1, So-Youn Min1
1Department of Medicine, Division of Rheumatology, Center for Rheumatoid Diseases and Rheumatism Research Center (RhRC), Catholic Research Institutes of Medical Sciences, Catholic University of Korea, Seoul, Republic of Korea.
Abstract:
Type II collagen (CII) is expressed exclusively in the joint articular. Although the relationship between anti-CII immunity and human rheumatoid arthritis (RA) has been studied for a long time, definitive conclusions have not been reached. CII, as an autoantigen, has been studied extensively in small animal models, such as mice, and the collagen-induced arthritis (CIA) model has increased our understanding of the pathogenesis of human RA. In the present report, we summarize the available information on anti-CII immunity and discuss recent updates regarding pathogenesis in the CIA model, including the role of Th17 cells.
