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Updated: Jul 10, 2026

Electromechanical Assessment of Optogenetically Modulated Cardiomyocyte Activity
Published on: March 5, 2020
Getting a G--RRP on regulated exocytosis in the heart
1Department of Biology, The SDSU Heart Institute and San Diego State University, San Diego, CA 92182, USA. cglembotski@sciences.sdsu.edu
Abstract:
A study by Rybkin et al. (see p. 527) substantially advances our understanding of regulated exocytois by specialized secretory cells, such as atrial myocytes. A second member of the Ras-related protein family, RRP17, was identified and shown to participate in regulating the secretion of the cardiac-derived peptide hormone, atrial natriuretic peptide. In addition to the heart, RRP17 was shown to be expressed in neuronal, pancreatic, and skeletal muscle cells, suggesting a widespread role in regulated secretion for this new protein.
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