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Weight fluctuations and risk for metabolic syndrome in an adult cohort

A-C Vergnaud1, S Bertrais, J-M Oppert

  • 1Nutritional Epidemiology Unit, UMR U557 INSERM, U1125 INRA, CNAM, Centre de Recherche en Nutrition Humaine Ile-de-France, Bobigny, France.

International Journal of Obesity (2005)
|October 31, 2007
PubMed
Abstract

Insights

Weight fluctuations (WF) are a significant risk factor for metabolic syndrome (MS). Maintaining weight stability is crucial for preventing MS, as even no weight fluctuations can indicate underlying weight gain risks.

Area of Science:

  • Metabolic health
  • Cardiovascular risk factors
  • Obesity research

Background:

  • Weight gain is a known risk factor for metabolic syndrome (MS).
  • The impact of weight fluctuations (WF) on MS risk remains unclear.
  • Investigating WF association with MS is crucial for public health.

Purpose of the Study:

  • To investigate the association between weight fluctuations (WF) and the risk of developing metabolic syndrome (MS).
  • To determine if weight stability or instability influences MS development in middle-aged adults.

Main Methods:

  • Assessed MS status using NCEP-ATP III criteria at baseline and after 7 years.
  • Estimated weight fluctuations (WF) using four weight measures during follow-up.
  • Analyzed odds ratios for incident MS cases across WF groups in 3553 middle-aged subjects.

Main Results:

  • The third WF tertile showed a 2.06-fold increased risk for MS compared to the first tertile.
  • Subjects with no WF had a 2.72-fold higher risk for MS, linked to significant weight gain.
  • Associations were independent of relative weight change and observed for MS components like raised blood pressure and increased waist circumference.

Conclusions:

  • Weight fluctuations (WF) are an independent risk factor for metabolic syndrome (MS) over a 7-year follow-up.
  • Individuals with no WF may still be at risk due to substantial weight gain, highlighting the importance of weight stability.
  • These findings underscore the benefits of weight stability and the critical need for weight gain prevention from early adulthood.

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