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Preparation and Characterization of SDF-1α-Chitosan-Dextran Sulfate Nanoparticles
Published on: January 22, 2015
Dexamethasone sodium phosphate-loaded Chitosan based delivery systems for buccal application
R Pignatello1, A H S Stancampiano, C A Ventura
1Dipartimento di Scienze Farmaceutiche, Università degli Studi di Catania, Catania, Italy. r.pignatello@unict.it
Journal of Drug Targeting
|October 31, 2007
Summary
Chitosan (CH) polymer systems were developed for sustained release of dexamethasone sodium phosphate (DSP) for mouth diseases. The 2:1 CH-DSP solid dispersion showed promising prolonged drug release for further investigation.
Area of Science:
- Polymer Science
- Pharmaceutics
- Drug Delivery Systems
Background:
- Chitosan (CH) is a biocompatible and bioadhesive polymer.
- Dexamethasone sodium phosphate (DSP) is a steroidal anti-inflammatory drug used for mouth diseases.
Purpose of the Study:
- To prepare and characterize CH-based solid dispersions and hydrogels loaded with DSP.
- To evaluate the in vitro and in vivo drug release profiles of these systems.
Main Methods:
- Preparation of binary solid dispersions by freeze-drying and hydrogels.
- Characterization of swelling behavior and in vitro drug release.
- In vivo buccal application studies.
Main Results:
- Good physical compatibility between CH and DSP was observed.
- Both solid dispersions and hydrogels exhibited slow and prolonged in vitro DSP release.
- Swelling properties of CH influenced drug release at oral pH.
- In vivo buccal application demonstrated prolonged DSP release compared to a simple solution.
Conclusions:
- CH-based solid dispersions and hydrogels are effective systems for prolonged DSP delivery.
- The 2:1 CH-DSP solid dispersion demonstrated particularly favorable characteristics for further development.
- Polymer swelling is a key factor in controlling drug release in oral environments.
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