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Morphing steady-state free precession.

O Bieri1, S Patil, H H Quick

  • 1MR Physics, Department of Medical Radiology, University of Basel, Basel, Switzerland. oliver.bieri@unibas.ch

Magnetic Resonance in Medicine
|October 31, 2007
PubMed
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This study introduces morphing steady-state free precession (SSFP) for MRI, enabling positive contrast visualization from magnetic field distortions. This technique enhances visualization of interventional devices and super-paramagnetic iron oxide particles.

Area of Science:

  • Magnetic Resonance Imaging
  • Biomedical Engineering
  • Medical Physics

Background:

  • Standard MRI techniques struggle with visualizing positive contrast from susceptibility-related magnetic field distortions.
  • Unbalanced steady-state free precession (SSFP) is sensitive to magnetic field variations, but signal suppression is a limitation.

Purpose of the Study:

  • To present and evaluate a novel concept, "morphing SSFP," for generating positive contrast in MRI.
  • To investigate the feasibility of detecting marker materials for interventional MRI using this technique.
  • To explore applications in contrast-enhanced MRI and particle tracking.

Main Methods:

  • Theoretical and experimental investigation of morphing SSFP signal dependencies on sequence parameters (flip angle, repetition time).

Related Experiment Videos

  • Evaluation of local gradient compensation and frequency matching principles.
  • In vitro and in vivo feasibility studies for marker material detection.

    • Main Results:

    • Morphing SSFP leverages local gradient compensation to shift from unbalanced to balanced SSFP (bSSFP).
    • At low flip angles, unbalanced SSFP signals are suppressed, while bSSFP yields hyperintense signals against a dark background.
    • Successful detection of marker materials for interventional MRI was demonstrated.

    Conclusions:

    • Morphing SSFP offers a novel method for positive contrast visualization from susceptibility effects.
    • The technique shows promise for passive tracking of interventional devices and positive contrast generation using super-paramagnetic iron oxide (SPIO) particles.
    • This approach enhances capabilities in contrast-enhanced MRI and particle tracking applications.