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Temperature evolution during compaction of pharmaceutical powders.
Antonios Zavaliangos1, Steve Galen, John Cunningham
1Department of Materials Science and Engineering, Drexel University, Philadelphia, Pennsylvania 19104, USA. azavalia@coe.drexel.edu
Journal of Pharmaceutical Sciences
|October 31, 2007
Summary
This study presents a numerical method to predict tablet compaction temperatures. The model accurately captures transient temperature changes, validated by infrared measurements.
Area of Science:
- Pharmaceutical Engineering
- Computational Mechanics
- Materials Science
Background:
- Tablet compaction generates heat, influencing drug stability and tablet properties.
- Experimental temperature measurement during compaction is challenging due to test limitations.
Purpose of the Study:
- To develop and validate a numerical model for predicting transient temperature evolution during tablet compaction.
- To investigate the influence of compaction parameters on temperature fields.
Main Methods:
- Coupled thermomechanical finite element analysis.
- Calibrated Drucker-Prager Cap plasticity model.
- Validation using infrared (IR) thermography of tablet surfaces.
Main Results:
- The numerical approach accurately predicts transient temperatures during compaction.
- Model captures the dependence of temperature on compaction speed and degree.
- Maximum temperatures occur at the tablet center and near the die wall.
Conclusions:
- The developed thermomechanical model provides a reliable tool for predicting compaction-induced temperatures.
- This approach overcomes experimental limitations in transient temperature assessment.
- Understanding temperature evolution is crucial for optimizing tablet manufacturing processes.
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