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Managing hypertension in diabetic patients--focus on trandolapril/verapamil combination

Sanjib Kumar Sharma1, Piero Ruggenenti, Giuseppe Remuzzi

  • 1Clinical Research Centre for Rare Diseases Aldo e Cele Daccò, Mario Negri Institute for Pharmacological Research,Villa Camozzi, Ranica, Italy.

Vascular Health and Risk Management
|November 1, 2007
PubMed

Insights

Hypertensive individuals with diabetes face higher risks. Aggressive blood pressure control using combination therapies like trandolapril/verapamil SR effectively reduces cardiovascular events and kidney disease progression.

Area of Science:

  • Cardiology
  • Nephrology
  • Endocrinology

Background:

  • Hypertensive individuals with diabetes are at increased risk for cardiovascular events and end-stage renal disease.
  • Aggressive hypertension management in diabetic patients is proven to reduce these complications.
  • Combination antihypertensive therapy is often necessary to achieve target blood pressure and improve outcomes.

Purpose of the Study:

  • To evaluate the efficacy of trandolapril/verapamil sustained release (SR) in hypertensive diabetic patients.
  • To assess the role of renin-angiotensin system blockade in this patient population.
  • To determine the effectiveness of fixed-dose trandolapril/verapamil SR in managing hypertension and preventing complications.

Main Methods:

  • Analysis of data from large clinical trials, including the INVEST and BENEDICT trials.
  • Evaluation of a verapamil SR-based treatment strategy including trandolapril.
  • Assessment of trandolapril plus verapamil versus trandolapril alone in hypertensive diabetics with normoalbuminuria.

Main Results:

  • Trandolapril/verapamil SR is indicated for hypertension in patients needing multiple drugs to reach target blood pressure.
  • The INVEST trial showed a verapamil SR-based strategy (including trandolapril) reduced primary outcomes in hypertensive patients with coronary artery disease.
  • The BENEDICT trial demonstrated that trandolapril plus verapamil delayed microalbuminuria onset in hypertensive diabetics, independent of blood pressure reduction.

Conclusions:

  • Trandolapril/verapamil SR is an effective treatment option for hypertensive diabetic patients.
  • This combination therapy helps achieve target blood pressure and improve cardiovascular and renal outcomes.
  • The drug combination shows promise in delaying the onset of diabetic kidney disease complications.

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