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Updated: Jul 10, 2026
Affinity Purification of Influenza Virus Ribonucleoprotein Complexes from the Chromatin of Infected Cells
Published on: June 3, 2012
Purification and cloning of interferon alpha.
1Department of Molecular Genetics, Microbiology and Immunology, Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA. Pestka@umdnj.edu
Interferon alpha (IFN-alpha) gained FDA approval in 1986, marking a milestone in cytokine development. Further research is needed to fully understand the diverse roles of human interferons and their genes.
Area of Science:
- Immunology
- Molecular Biology
- Biochemistry
Background:
- The US FDA approved Interferon alpha (IFN-alpha) in 1986, initiating advancements in cytokine and growth factor research.
- Despite this progress, the full spectrum of human interferons (IFNs) remains largely unexplored.
Observation:
- This review details the historical purification process of human leukocyte IFN.
- It covers the subsequent cloning of various IFN-alpha subtypes.
Findings:
- The paper synthesizes the current understanding of human interferon alpha genes.
- It also reviews the existing knowledge regarding human interferon alpha proteins.
Implications:
- Understanding human interferon alpha genes and proteins is crucial for future therapeutic developments.
- Further research into the diverse human IFNs is warranted to unlock their full potential.
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