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Related Experiment Video

Updated: Jul 10, 2026

Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis

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Published on: June 24, 2018

[Annexin in mineralization process].

Anna Sekrecka¹, Marcin Balcerzak, Cyril Thouverey

¹Zakład Biochemii Komórki, Instytut Biologii Doświadczalnej PAN im. Marcelego Nenckiego, Warszawa.

Postepy Biochemii

|November 1, 2007

Summary

Annexins are crucial for mineralization, regulating cells and forming mineral phases. This review explores their structure-function relationships in these processes.

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Area of Science:

Biochemistry
Cell Biology
Biomineralization

Context:

Annexins are proteins involved in various cellular functions.
Mineralization is a critical biological process involving mineral deposition.
Extracellular matrix formation is essential for tissue development and integrity.

Purpose:

To review the diverse roles of annexins in the mineralization process.
To elucidate the structure-function relationships of annexins in biomineralization.
To highlight annexins' involvement in regulating mineralization-competent cells and mineral phase formation.

Summary:

Annexins play a vital role in mineralization by regulating cells and directly contributing to mineral phase formation in the extracellular matrix.
Their functions are linked to their ability to bind to biological membranes in a calcium-dependent and independent manner.
This review focuses on the structure-function aspects of annexins within the context of mineralization.

Impact:

Provides insights into the molecular mechanisms of biomineralization.
Identifies potential therapeutic targets for diseases involving abnormal mineralization.
Enhances understanding of annexin protein family's versatility in biological processes.