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Acute parkinsonian syndrome with demyelinating leukoencephalopathy in bone marrow transplant recipients
L A Lockman1, J H Sung, W Krivit
1Division of Pediatric, University of Minnesota Medical School, Minneapolis.
Pediatric Neurology
|November 1, 1991
Abstract:
A syndrome of rigidity, bradykinesia, spasticity, and often myoclonus and dementia developed acutely in 5 patients who had undergone successful engraftment of bone marrow transplants for the treatment of various hematologic diseases. Magnetic resonance imaging demonstrated widespread changes in white matter; brain biopsy disclosed mild demyelination associated with active phagocytosis of myelin. One patient, who was not treated, remains severely demented. Patients treated with very high-dose methylprednisolone had complete clinical recovery.