Related Experiment Video
Updated: Jul 10, 2026
07:46
Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
Published on: April 3, 2017
[Inflammatory biomarkers: the link between obesity and associated pathologies]
Ma A Zulet1, B Puchau, C Navarro
1Departamento de Ciencias de la Alimentación, Fisiología y Toxicología, Universidad de Navarra, Pamplona, España.
Nutricion Hospitalaria
|November 1, 2007
Summary
Inflammation, obesity, and related diseases are linked by numerous biomarkers. While some predict cardiovascular risk and insulin resistance, their precise roles in human inflammatory processes require further investigation.
Area of Science:
- Biochemistry
- Immunology
- Metabolic Disorders
Background:
- Growing evidence links inflammation to major public health issues.
- Obesity is increasingly recognized as an inflammatory disorder.
- Oxidative stress may induce inflammation and susceptibility to obesity-related diseases.
Purpose of the Study:
- To review biomarkers associated with inflammation, obesity, and comorbidities.
- To identify knowledge gaps regarding these biomarkers' roles and regulation.
Main Methods:
- Literature review of recent studies on inflammation and obesity biomarkers.
- Analysis of proposed biomarkers and their associations with health outcomes.
Main Results:
- Numerous biomarkers identified, including TNF-α, IL-6, IL-18, leptin, resistin, CRP, and adiponectin.
- Specific biomarkers (e.g., PAI-1, sialic acid, CRP) show predictive value for cardiovascular risk, adiposity, and insulin resistance.
- Many biomarkers' roles in human inflammatory processes remain unclear.
Conclusions:
- Biomarkers play a crucial role in the interplay between inflammation, obesity, and metabolic disorders.
- Further research is needed to elucidate the exact functions and regulatory mechanisms of these biomarkers in humans.
Related Concept Videos
01:24Obesity
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:30Coronary Artery Disease I: Introduction
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
01:25Inflammatory Bowel Disease III: Crohn's Disease
Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
01:18Dysbiosis of the Gut Microbiota
The human gut microbiome includes a diverse array of microbial species, including beneficial commensals and opportunistic pathogens, which interact to support host health. These microbes contribute to essential functions such as nutrient metabolism, immune system modulation, and maintenance of intestinal barrier integrity. However, disruptions to this equilibrium—referred to as dysbiosis—can have widespread physiological consequences.Dysbiosis is often characterized by reduced microbial...
01:12Chronic Inflammation: Introduction
Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...