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Updated: Jul 10, 2026

Amikacin Protection Assay for Quantification and Visualization of Escherichia coli Cell Invasion
Published on: July 3, 2026
Biodegradable gentamicin delivery systems for parenteral use for the treatment of intracellular bacterial infections
Carlos Gamazo1, Sandra Prior, María Concepción Lecároz
1University of Navarra, Department of Microbiology, 31080 Pamplona, Spain. cgamazo@unav.es
Abstract:
Gentamicin is an aminoglycoside with a wide spectrum of antibacterial activity. However, as a highly water-soluble drug, it penetrates cells poorly. This constitutes a particularly important drawback for treating intracellular bacterial infections. This major hurdle may be solved by the use of vectors to deliver and target bioactive agents to the intracellular sites of infection. Thus, in the case of antimicrobials, drug delivery systems may help to increase their therapeutic index in intracellular locations. The development and evolution of pharmaceutical forms of gentamicin for the parenteral treatment of intracellular pathogens is reviewed in this paper.
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