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Updated: Jul 10, 2026

Mouse In Vivo Placental Targeted CRISPR Manipulation
Published on: April 14, 2023
Epigenetic control of fetal gene expression
T M Nafee1, W E Farrell, W D Carroll
1Academic Unit of Obstetrics and Gynaecology, Keele University Medical School, University Hospital of North Staffordshire, Stoke-on-Trent, Staffordshire, UK.
Abstract:
Each differentiated cell type has its own epigenetic signature, which reflects its genotype, developmental history, and environmental influences, and is ultimately reflected in the phenotype of the cell and organism. Some cells undergo major epigenetic 'reprogramming' during fetal development. The proper, or improper, handling of these highly sensitive periods may have significant short-term and long-term effects on the newborn and his/her progeny. This review highlights the impact of environmental and nutritional factors on the epigenome and the potential effect of epigenetic dysregulation on maternal and fetal pregnancy outcomes, as well as possible long-term implications.
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