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Updated: Jul 10, 2026

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

Published on: November 9, 2016

Current issues for nurse practitioners: Hyponatremia.

¹Tuberculosis Treatment Unit, Lemuel Shattuck Hospital, Jamaica Plain, Massachusetts 02130, USA. Ruth.Haskal@state.ma.us

Journal of the American Academy of Nurse Practitioners

|November 1, 2007

Summary

This summary is machine-generated.

Hyponatremia, a common electrolyte imbalance, requires prompt diagnosis and treatment. New arginine vasopressin (AVP) receptor antagonists offer a safe and effective treatment option for hospitalized patients.

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Last Updated: Jul 10, 2026

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

Published on: November 9, 2016

Area of Science:

Nephrology
Endocrinology
Internal Medicine

Background:

Hyponatremia (serum sodium <135 mEq/L) is the most common electrolyte disturbance, often resulting from water balance dysregulation in hospitalized patients.
Risk factors include advanced age, heart failure, cirrhosis, head injury, surgery, and certain medications.

Observation:

A thorough understanding of water balance physiology and risk factors is crucial for effective hyponatremia intervention.
Conventional therapies have limitations, necessitating awareness of newer treatment options.

Findings:

Arginine vasopressin (AVP) receptor antagonists, also known as aquaretics, have demonstrated safety and efficacy in clinical trials for hyponatremia treatment.
Intravenous conivaptan hydrochloride is the first approved AVP receptor antagonist for treating euvolemic hyponatremia in hospitalized patients.

Implications:

Prompt diagnosis and management of hyponatremia are essential to prevent adverse patient outcomes.
The availability of AVP receptor antagonists allows for optimized patient care by addressing limitations of conventional therapies.