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Repeated exposures to hyperbaric air suppress neurite outgrowth in PC12 cells
Tetsuro Isada1, Munetaka Hirose, Eri Murata
1Department of Anesthesiology and Reanimatology, Faculty of Medical Sciences, Fukui University, Eiheijicho, Yoshidagun, Fukui, 910-1193, Japan.
The Journal of Physiological Sciences : JPS
|November 1, 2007
Abstract:
Hyperbaric exposure induces lesions of the CNS in scuba divers. Repeated exposures to hyperbaric air at 0.5 MPa for 30 min with short intervals suppressed NGF-stimulated neurite outgrowth, concomitant with a decrease in the protein expression of ERK in PC12 cells. Hyperbaric exposure most likely causes direct lesions of neural cells.
