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Transcriptional regulation of MMP13 by Lef1 in chondrocytes

Kangsun Yun1, Sin-Hyeog Im

  • 1Department of Life Sciences, Gwangju Institute of Science and Technology, 1 Oryong-dong, Puk-ku, Gwangju 500-712, Republic of Korea.

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Role of Matrix Metalloproteases in Degradation of ECM

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A...
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Regulation of Expression at Multiple Steps

The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the addition of a...
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Chromatin Structure Regulates pre-mRNA Processing

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The chromatin structure, especially...