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Mortality in acromegaly: a metaanalysis.

O M Dekkers1, N R Biermasz, A M Pereira

  • 1Department of Endocrinology and Metabolic Diseases C4-R, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands. o.m.dekkers@lumc.nl

The Journal of Clinical Endocrinology and Metabolism
|November 1, 2007
PubMed
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This meta-analysis confirms increased all-cause mortality in acromegaly patients compared to the general population. Even with transsphenoidal surgery, acromegaly patients face a higher mortality risk.

Area of Science:

  • Endocrinology
  • Oncology

Background:

  • Acromegaly patient mortality risk requires further investigation.
  • Previous studies indicate elevated mortality but lack statistical significance.
  • Formal establishment of acromegaly's impact on mortality is pending.

Purpose of the Study:

  • To investigate the all-cause mortality risk in acromegaly patients.
  • To analyze mortality data through a comprehensive meta-analysis.

Main Methods:

  • A meta-analysis of sixteen studies on acromegaly mortality.
  • Calculation of the weighted average standardized mortality ratio (SMR).
  • Subgroup analysis for patients treated primarily via transsphenoidal approach.

Main Results:

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  • The overall weighted mean SMR was 1.72 (95% CI 1.62-1.83).
  • For studies with transsphenoidal surgery as primary therapy, the weighted mean SMR was 1.32 (95% CI 1.12-1.56).

Conclusions:

  • Acromegaly is associated with increased all-cause mortality compared to the general population.
  • Elevated mortality risk persists even after transsphenoidal surgery for acromegaly.