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Antitoxic properties of a preparation of glutathione S-transferase
E V Kalinina1, V N Nechaev, A N Saprin
1All-Union Research Institute of Biotechnology, Ministry of Medical Industry of the USSR, Moscow.
Biomedical Science
|January 1, 1991
Abstract:
Pretreatment of rats with a preparation of the cationic form of rat liver cytosolic glutathione S-transferase 1-3 h before injection of a dose of N-nitroso-N-diethylamine equivalent to the LD50 of the drug completely protects the animals against the toxic effects of the drug. The mechanism of the protective action of glutathione S-transferase is discussed.