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Detection of Rare Mutations in CtDNA Using Next Generation Sequencing

Detection of Rare Mutations in CtDNA Using Next Generation Sequencing

Published on: August 24, 2017

Errors in cancer diagnosis: current understanding and future directions.

Hardeep Singh¹, Saurabh Sethi, Martin Raber

¹Health Policy and Quality Program, Houston Center for Quality of Care and Utilization Studies, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX 77030, USA. hardeeps@bcm.tmc.edu

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology

|November 1, 2007

Summary

Cancer diagnostic errors are common and costly, impacting melanoma, breast, colon, and lung cancers. Understanding error origins and implementing interdisciplinary interventions are key to improving patient outcomes and reducing healthcare expenses.

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Area of Science:

Medical Diagnostics
Oncology
Patient Safety

Background:

Diagnostic errors in cancer are exceptionally harmful and expensive.
Focus on common cancers with high benefit from early detection: melanoma, breast, colon, and lung.

Purpose of the Study:

To review literature on the prevalence, origins, and prevention of cancer diagnostic errors.
To identify key areas for improvement in cancer diagnosis.

Main Methods:

Comprehensive literature search of Cochrane Library and PubMed (1966-2007).
Manual reference searching of key publications.
Analysis of 110 studies (9 prospective, 101 retrospective).

Main Results:

Cancer diagnostic errors are frequent, evidenced by autopsy and malpractice claim data.
Errors stem from clinical encounters, diagnostic procedures, pathology, follow-up, and patient delays.
Prevalence data is limited, particularly for prospective studies.

Conclusions:

Knowledge is advanced for procedural/imaging errors, with emerging understanding of pathology errors.
Gaps exist in prospective studies and research on clinical encounter/follow-up errors.
Future research should address systemic, cognitive factors, and interdisciplinary interventions for error prevention.