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Updated: Jul 10, 2026

Engineering Antiviral Agents via Surface Plasmon Resonance
Published on: June 14, 2022
Synthesis and antiviral bioactivities of alpha-aminophosphonates containing alkoxyethyl moieties
Yingshu Xu1, Kai Yan, Baoan Song
1Center for Research and Development of Fine Chemicals, Guizhou University, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guiyang, 550025, PR China. xuyingshu1976@126.com
Abstract:
A simple, efficient, and general method has been developed for the synthesis of various alpha-aminophosphonate derivatives 4a-4l by treatment of substituted benzaldehydes and aniline with bis(2-methoxyethyl)- or bis(2-ethoxyethyl) phosphite under microwave irradiation without solvents and catalysts. The products were characterized by elemental analysis, IR, 1H-NMR, 13C- and 31P-NMR spectra. The X-ray crystallographic data of the representative compound 4l was determined. The new alpha-aminophosphonate derivatives were found to possess moderate to good antiviral activity.
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