Related Experiment Video
Updated: Jul 10, 2026

Stabilizing Hepatocellular Phenotype Using Optimized Synthetic Surfaces
Published on: September 26, 2014
Copolymers for hepatocyte-specific targeting carrying galactose and hydrophobic alkyl groups
Takahiro Hiratsuka1, Mitsuaki Goto, Yoshiyuki Kondo
1Department of Biomolecular Engineering, Tokyo Institute of Technology, Yokohama 226-8501, Japan. takaike@bio.titech.ac.jp
Abstract:
Core-forming hydrophobic alkyl groups were incorporated into amphiphilic PVLA to enhance the stability and inclusion ability of the homopolymeric micelles in water. The CAC and hepatocyte targeting in the synthesized P(VLA-co-VBH) were investigated in vitro. The CAC of the copolymers decreased and the stability of the copolymeric micelles increased with the incorporation of hydrophobic groups into the homopolymer. The galactose moieties in the copolymer could be recognized by the ASGP-R of the hepatocytes through a receptor-mediated mechanism. The copolymers efficiently delivered a water-insoluble drug to the hepatocytes. Hence, they be used to deliver hydrophobic drugs to cure various liver diseases.
More Related Videos
10:54Facile and Efficient Preparation of Tri-component Fluorescent Glycopolymers via RAFT-controlled Polymerization
Published on: June 19, 2015
10:18Fabrication of Inverted Colloidal Crystal Poly(ethylene glycol) Scaffold: A Three-dimensional Cell Culture Platform for Liver Tissue Engineering
Published on: August 27, 2016
Related Concept Videos
Site-Targeted Drug Delivery Systems: Polymeric Carriers
Proteoglycans
Matrix Proteoglycans and Glycoproteins
Drug Metabolism: Phase II Reactions