Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Development of the Lymphatic System01:15

Development of the Lymphatic System

The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
Functions of the Lymphatic and Immune System01:28

Functions of the Lymphatic and Immune System

The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A comparative study of organoid-derived and cell line-derived intestinal epithelial models.

PloS one·2026
Same author

Phosphoinositide 3-kinase δ activity in patients with systemic lupus erythematosus.

Frontiers in immunology·2026
Same author

TLR ligand sensing by lymph node FRCs directs intranodal lymphocyte accumulation to promote immune responses.

iScience·2025
Same author

Enhanced MHC Class-II Expression in Fibroblastic Reticular Cells Associates with Maturation.

European journal of immunology·2025
Same author

Exploring patients' views on a more proactive role for allied healthcare professionals in the identification of suspicious skin lesions: a qualitative study.

The British journal of dermatology·2025
Same author

Integration of lymphatic vasculature to a human lymph node-on-chip enhances physiological immune properties.

Materials today. Bio·2025

Related Experiment Video

Updated: Jul 10, 2026

Generation of Lymph Node-fat Pad Chimeras for the Study of Lymph Node Stromal Cell Origin
09:10

Generation of Lymph Node-fat Pad Chimeras for the Study of Lymph Node Stromal Cell Origin

Published on: December 16, 2013

Lymphoid organogenesis in brief.

Mark F R Vondenhoff1, Georg Kraal, Reina E Mebius

  • 1Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands.

European Journal of Immunology
|November 1, 2007
PubMed
Summary
This summary is machine-generated.

Modern immunology research shifted from molecular to cell-oriented studies, focusing on lymphocyte differentiation and lymphoid organ development. Understanding these processes is crucial for advancing our knowledge of the immune system.

More Related Videos

Characterization of Thymic Settling Progenitors in the Mouse Embryo Using In Vivo and In Vitro Assays
08:56

Characterization of Thymic Settling Progenitors in the Mouse Embryo Using In Vivo and In Vitro Assays

Published on: June 9, 2015

Visualizing Lymph Node Structure and Cellular Localization using Ex-Vivo Confocal Microscopy
07:40

Visualizing Lymph Node Structure and Cellular Localization using Ex-Vivo Confocal Microscopy

Published on: August 9, 2019

Related Experiment Videos

Last Updated: Jul 10, 2026

Generation of Lymph Node-fat Pad Chimeras for the Study of Lymph Node Stromal Cell Origin
09:10

Generation of Lymph Node-fat Pad Chimeras for the Study of Lymph Node Stromal Cell Origin

Published on: December 16, 2013

Characterization of Thymic Settling Progenitors in the Mouse Embryo Using In Vivo and In Vitro Assays
08:56

Characterization of Thymic Settling Progenitors in the Mouse Embryo Using In Vivo and In Vitro Assays

Published on: June 9, 2015

Visualizing Lymph Node Structure and Cellular Localization using Ex-Vivo Confocal Microscopy
07:40

Visualizing Lymph Node Structure and Cellular Localization using Ex-Vivo Confocal Microscopy

Published on: August 9, 2019

Area of Science:

  • Immunology
  • Developmental Biology
  • Cell Biology

Background:

  • Immunological research has evolved from molecular and serological approaches to a cell-oriented focus.
  • Key areas of study include hematopoietic differentiation, cell-cell interactions, cellular activation, and cell migration.
  • The development of mutant mice lacking lymphoid organs has enabled detailed dissection of lymphoid organogenesis.

Purpose of the Study:

  • To highlight the paradigm shift in immunology towards cellular and developmental aspects.
  • To emphasize the importance of lymphoid organs in lymphocyte differentiation and immune system function.
  • To outline the current understanding of lymphoid organogenesis at cellular and molecular levels.

Main Methods:

  • Review of historical trends in immunological research.
  • Analysis of studies utilizing mutant mouse models lacking lymphoid organs.
  • Integration of findings on cellular and molecular mechanisms in lymphoid organ development.

Main Results:

  • Lymphocyte diversity and lymphoid organ roles are central to modern immunology.
  • Lymphoid organogenesis can be studied through distinct developmental phases involving specific cells and molecules.
  • Mutant mouse models have been instrumental in dissecting organogenesis at cellular and molecular levels.

Conclusions:

  • The field has successfully transitioned to a cell-centric view of immunology.
  • Significant progress has been made in understanding lymphoid organ development phases and key players.
  • Further research is needed to fully elucidate all molecules and cells involved in lymphoid organ formation.