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Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
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Published on: September 9, 2012

Vitamin C protective plasma value.

M Krajcovicova-Kudlackova1, K Babinska, M Valachovicova

  • 1Slovak Medical University, Bratislava, Slovakia. marica.kudlackova@szu.sk

Bratislavske Lekarske Listy
|November 2, 2007
PubMed
Summary
This summary is machine-generated.

Vegetarians have significantly higher plasma vitamin C levels than the general population, offering better protection against free radical diseases. Many in the general population have suboptimal vitamin C, indicating a need for dietary changes.

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Area of Science:

  • Nutrition Science
  • Biochemistry
  • Public Health

Background:

  • Plasma vitamin C concentrations are crucial for antioxidative protection and disease prevention.
  • Suboptimal vitamin C levels are prevalent in the general population, impacting health.
  • Vegetarian diets are often associated with higher nutrient intake, including vitamin C.

Purpose of the Study:

  • To investigate the relationship between plasma vitamin C concentrations, dietary intake, and oxidative damage in vegetarians and the general population.
  • To assess the adequacy of current vitamin C recommendations in Slovakia.
  • To highlight the role of vitamin C in preventing free radical-related diseases.

Main Methods:

  • Plasma vitamin C levels and dietary intake were measured in 368 healthy adults (187 general population, 181 vegetarians).
  • Subjects were categorized based on plasma vitamin C concentrations (deficient, suboptimal, protective).
  • Markers of oxidative damage to DNA, lipids, and proteins were analyzed.

Main Results:

  • Vegetarians exhibited significantly higher plasma vitamin C concentrations and a higher prevalence of protective levels (88%) compared to the general population (46%).
  • The general population showed a high prevalence of vitamin C deficiency or suboptimal levels, with insufficient antioxidative protection.
  • Subjects with protective plasma vitamin C concentrations (>50 micromol/l) had significantly reduced markers of oxidative damage.

Conclusions:

  • Higher plasma vitamin C concentrations, particularly in vegetarians, are associated with reduced oxidative stress and better protection against free radical diseases.
  • Current recommended dietary allowances for vitamin C in Slovakia may be insufficient for optimal health in the general population.
  • Dietary habits, including increased fruit and vegetable consumption, need revision to improve vitamin C status and reduce disease risk.