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[Preparation of kangfuxin colon targeting micro-pellets]
Ming Yang1, Xue-lan Qiu, Xing-liang Xie
1Chengdu University of Traditional Chinese Medicine, Chengdu 611730, China.
Objective:
To prepare coated micro-pellets of pH-dependent and enzyme-dependent kangfuxin colon targeting delivery system, to make them go to colon, then release, educe partial effect.
Method:
We eploy pan-pill to prepare simple pellets, and prepare tunicatus pellets with fluidized bed coating. We investigated the preparation and parameter of pellets, so, we bolting the best shaping and tunicatus artwork.
Result:
The ingredients for preparing the micro-pellets are 125% starch +2% CMC-Na, and add 30% ethanol to be binder, pellets were coated with Eudragit S100 to prepare ph-dependent and pectin-HPMC to prepare enzyme-dependent colon targeting micro-pellets.
Conclusion:
We get two micro-pellets of pH-dependent and enzyme-dependent kangfuxin colon targeting.
