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Updated: Jul 10, 2026
09:43
Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
[Lupus nephritis in children and adolescents (clinical-morphologic correlation)]
Srpski Arhiv Za Celokupno Lekarstvo
|January 1, 1994
Summary
Lupus nephritis in children and adolescents often presents with proteinuria and hematuria. Proliferative lupus nephritis, indicated by severe kidney dysfunction, is linked to specific clinical signs and decreased serum C3 levels.
Area of Science:
- Pediatric Nephrology
- Rheumatology
- Pathology
Context:
- Lupus nephritis affects children and adolescents, impacting kidney function.
- Renal biopsy is crucial for diagnosing and classifying lupus nephritis.
- Understanding clinical and laboratory features aids in predicting disease severity.
Purpose:
- To analyze clinical and laboratory features of lupus nephritis in pediatric patients.
- To correlate these features with histopathological findings from renal biopsies.
- To identify predictors of proliferative lupus nephritis.
Summary:
- This study analyzed 27 pediatric patients with lupus nephritis, correlating clinical signs with renal biopsy findings.
- Common manifestations included proteinuria, hematuria, and nephrotic syndrome.
- Severe renal dysfunction (nephrotic syndrome, decreased GFR, hypertension) was associated with proliferative lupus nephritis (WHO classes III and IV).
- Nephrotic syndrome, hematuria, and low serum C3 levels predicted proliferative disease.
Impact:
- Identifies key clinical indicators for proliferative lupus nephritis in children.
- Enhances diagnostic accuracy and prognostic assessment in pediatric lupus nephritis.
- Provides valuable insights for targeted treatment strategies in pediatric rheumatology and nephrology.
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