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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

Relationship between markers of activated coagulation, their correlation with inflammation, and association with

G J Miller1, H A Ireland, J A Cooper

  • 1MRC Cardiovascular Research Group, Wolfson Institute for Preventive Medicine, London, UK.

Journal of Thrombosis and Haemostasis : JTH
|November 2, 2007
PubMed

Insights

Inflammation minimally impacts coagulation activation markers (CAMs). Reduced activated factor VII (FVIIa) and increased factor IX peptides (FIXpep) independently predict coronary heart disease (CHD).

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Biochemistry

Background:

  • Inflammation and coagulation are implicated in coronary heart disease (CHD) pathogenesis.
  • Coagulation activation markers (CAMs) may reflect underlying thrombotic processes.
  • The relationship between inflammation and specific CAMs in relation to CHD risk is not fully elucidated.

Purpose of the Study:

  • To investigate the parallel increase of coagulation activation with inflammation.
  • To determine if CAMs are independently associated with incident coronary heart disease (CHD).

Main Methods:

  • Prospective study (NPHSII) of 2997 men aged 50-63.
  • Measured plasma levels of multiple CAMs: activated factor XII (FXIIa), FXpep, FIXpep, FVIIa, F1+2, FpA.
  • Used C-reactive protein (CRP) as a marker of inflammation.

Main Results:

  • Borderline to significant correlations were observed between most CAMs and CRP levels.
  • Fibrinogen showed the highest correlation with CRP.
  • Activated factor VII (FVIIa) and FIXpep demonstrated independent associations with CHD risk.

Conclusions:

  • Inflammation has a minimal impact on CAMs of the extrinsic coagulation pathway.
  • Reduced FVIIa levels are associated with increased CHD risk.
  • Increased FIXpep levels are associated with increased CHD risk.
Abstract

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