Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nail pigmentation due to hydroxycarbamide.

Roeland P M Ceulen1, Jorge Frank, Pamela Poblete-Gutiérrez

  • 1Department of Dermatology, University Hospital Maastricht, Maastricht, The Netherlands. rce@sder.azm.nl

International Journal of Dermatology
|December 6, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cutaneous and non-cutaneous diseases due to Mycoplasma pneumoniae in children.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2026
Same author

Beneath the surface: delineating the subtypes of Dowling-Degos disease.

The British journal of dermatology·2025
Same author

S2k guideline basal cell carcinoma of the skin (update 2023).

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2024
Same author

Proposing GLMN, encoding glomulin, as a novel gene for Dowling-Degos disease.

The British journal of dermatology·2024
Same author

CD24 flags anastasis in melanoma cells.

Apoptosis : an international journal on programmed cell death·2024
Same author

[An overview of porphyrias].

Dermatologie (Heidelberg, Germany)·2024
Same journal

SENTINOLD and the Challenge of Meaningful Risk Prediction in Melanoma.

International journal of dermatology·2026
Same journal

The "Stamp-n-Tack" Technique: An Ink-Guided Precision Method for Anchoring Tissue After Releasing Facial Retaining Ligaments in Large Facial Flap Reconstruction.

International journal of dermatology·2026
Same journal

Counterfactual Dermatology With Generative Models.

International journal of dermatology·2026
Same journal

Correlation of Clinical and Histopathological Features With Anti-Desmoglein Antibody Profile in Pemphigus Patients.

International journal of dermatology·2026
Same journal

Paracetamol-Induced Generalized Bullous Fixed Drug Eruption With Positive Anti-BP230 Antibody and Confirmed With Oral Provocation Test in a Child: A Case Report From the Philippines.

International journal of dermatology·2026
Same journal

Clinicopathological Challenge: A Painful Violaceous Reticulated Patch.

International journal of dermatology·2026
See all related articles

Hydroxycarbamide therapy can cause nail hyperpigmentation, specifically melanonychia, in patients with myeloproliferative diseases. This side effect requires careful differentiation from subungual malignant melanoma.

Area of Science:

  • Dermatology
  • Oncology

Background:

  • Hydroxycarbamide (hydroxyurea) is a key treatment for chronic myeloproliferative diseases.
  • Nail hyperpigmentation presents a diagnostic challenge with a broad differential spectrum.

Observation:

  • A 47-year-old male patient exhibited longitudinal melanonychia and periungual hyperpigmentation.
  • These symptoms emerged six months after commencing hydroxycarbamide therapy.

Findings:

  • Melanonychia and periungual hyperpigmentation are potential side effects of hydroxycarbamide treatment.
  • Distinguishing drug-induced melanonychia from subungual malignant melanoma is crucial.

Implications:

  • Awareness of hydroxycarbamide-induced nail changes is essential for clinicians.

Related Experiment Videos

  • Early differentiation between benign side effects and malignancy ensures appropriate patient management.